The BRCA1 tumor suppressor protein is a central constituent of several distinct
macromolecular protein complexes that execute homology-directed DNA damage repair
and cell cycle checkpoints. Recent years have borne witness to an exciting phase of
discovery at the basic molecular level for how this network of DNA repair proteins acts to
maintain genome stability and suppress cancer. The clinical dividends of this investment are
now being realized with the approval of first-in-class BRCA-targeted therapies for ovarian …