Rapid polyclonal desensitization with antibodies to IgE and FcεRIα
MV Khodoun, ZY Kucuk, RT Strait… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Rapid desensitization, a procedure in which persons allergic to an antigen
are treated at short intervals with increasing doses of that antigen until they tolerate a large
dose, is an effective, but risky, way to induce temporary tolerance. OBJECTIVE: We wanted
to determine whether this approach can be adapted to suppress all IgE-mediated allergies
in mice by injecting serially increasing doses of monoclonal antibodies (mAbs) to IgE or
FcεRIα. METHODS: Active and passive models of antigen-and anti-IgE mAb-induced IgE …
are treated at short intervals with increasing doses of that antigen until they tolerate a large
dose, is an effective, but risky, way to induce temporary tolerance. OBJECTIVE: We wanted
to determine whether this approach can be adapted to suppress all IgE-mediated allergies
in mice by injecting serially increasing doses of monoclonal antibodies (mAbs) to IgE or
FcεRIα. METHODS: Active and passive models of antigen-and anti-IgE mAb-induced IgE …