Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
BH Jiang, LZ Liu - Drug resistance updates, 2008 - Elsevier
The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation.
Deregulations in mTOR signaling are frequently associated with tumorigenesis,
angiogenesis, tumor growth and metastasis. This review highlights the role of the mTOR in
anticancer drug resistance. We discuss the network of signaling pathways in which the
mTOR kinase is involved, including the structure and activation of the mTOR complex and …
protein synthesis, ribosomal protein translation, and cap-dependent translation.
Deregulations in mTOR signaling are frequently associated with tumorigenesis,
angiogenesis, tumor growth and metastasis. This review highlights the role of the mTOR in
anticancer drug resistance. We discuss the network of signaling pathways in which the
mTOR kinase is involved, including the structure and activation of the mTOR complex and …