Angiotensin receptor binding in human hypothalamus: autoradiographic localization

MJ McKinley, AM Allen, J Clevers, G Paxinos… - Brain research, 1987 - Elsevier
MJ McKinley, AM Allen, J Clevers, G Paxinos, FAO Mendelsohn
Brain research, 1987Elsevier
Abstract Binding of 125 I-[Sar 1, Ile 8] angiotensin II in the human hypothalamus was
mapped by in vitro autoradiography carried out on frozen sections of hypothalamus from two
human brains. Regions showing the greatest specific binding of this radioligand were the
organum vasculosum of the lamina terminalis, median preoptic nucleus, subfornical organ,
median eminence, arcuate nucleus and paraventricular nucleus. These regions may be
sites of angiotensin II receptors involved in the regulation of blood pressure, fluid balance …
Abstract
Binding of 125I-[Sar1,Ile8]angiotensin II in the human hypothalamus was mapped by in vitro autoradiography carried out on frozen sections of hypothalamus from two human brains. Regions showing the greatest specific binding of this radioligand were the organum vasculosum of the lamina terminalis, median preoptic nucleus, subfornical organ, median eminence, arcuate nucleus and paraventricular nucleus. These regions may be sites of angiotensin II receptors involved in the regulation of blood pressure, fluid balance and pituitary hormone secretion.
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