[PDF][PDF] Understanding metabolic regulation and its influence on cell physiology

CM Metallo, MG Vander Heiden - Molecular cell, 2013 - cell.com
CM Metallo, MG Vander Heiden
Molecular cell, 2013cell.com
Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last
century, our knowledge of metabolic pathway architecture and the genomic landscape of
disease has increased exponentially. Combined with these insights, advances in analytical
methods for quantifying metabolites and systems approaches to analyze these data now
provide powerful tools to study metabolic regulation. Here we review the diverse
mechanisms cells use to adapt metabolism to specific physiological states and discuss how …
Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased exponentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology.
cell.com