Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis

JA Gorter, EA van Vliet, E Aronica - Epilepsy & Behavior, 2015 - Elsevier
Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature
and inflammation as important players in epileptogenic processes, with a specific emphasis
on failure of the blood–brain barrier (BBB; Fig. 1)(Seiffert et al., 2004; Marchi et al., 2007;
Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011)[3],[4],[5],[6],[7]. Here, we
discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown
may be involved in epileptogenesis. This article is part of a Special Issue entitled “Status …