Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

DE Fouts, M Torralba, KE Nelson, DA Brenner… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Intestinal dysbiosis and bacterial translocation are common in
patients with advanced liver disease, and there is strong evidence that the translocation of
bacteria and their products across the epithelial barrier drives experimental liver disease
progression. The aims of our study were to investigate dynamics of bacterial translocation
and changes in the enteric microbiome in early stages of liver disease. METHODS:
Cholestatic liver injury was induced by ligation of the common bile duct (BDL) and toxic liver …