In vivo treatment of mice with heat shock protein, gp96, improves survival of skin grafts with minor and major antigenic disparity
JT Kovalchin, C Mendonca, MS Wagh, R Wang… - Transplant …, 2006 - Elsevier
Immunization with high doses of heat shock protein, gp96 given in vivo, has been shown to
mediate the activation of CD4+ T cell, which in turn suppresses an ongoing CD8+ immune
response. Here we demonstrate that high doses of gp96 (HDgp96)(100 μg given
subcutaneously on days 0 and 7 following skin graft transplantation) improve survival of skin
grafts with both minor and major histocompatibility. First, skin from male C57BL/6 donors
was grafted onto female C57BL/6 recipients that were subsequently treated with either …
mediate the activation of CD4+ T cell, which in turn suppresses an ongoing CD8+ immune
response. Here we demonstrate that high doses of gp96 (HDgp96)(100 μg given
subcutaneously on days 0 and 7 following skin graft transplantation) improve survival of skin
grafts with both minor and major histocompatibility. First, skin from male C57BL/6 donors
was grafted onto female C57BL/6 recipients that were subsequently treated with either …