IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis
JI Engelhardt, SH Appel - Archives of neurology, 1990 - jamanetwork.com
• The spinal cord and motor cortex of patients with amyotrophic lateral sclerosis (ALS) were
examined with immunohistochemical methods for the presence of IgG. In 13 of 15 spinal
cords, a population of motoneurons stained positively for IgG in a granular pattern,
characteristic of binding to the rough endoplasmic reticulum. In 6 of 11 motor cortices, a
proportion of pyramidal cells also stained positively for IgG. No such reactivity was noted in
motoneurons of control human tissues, although positive IgG staining was present in …
examined with immunohistochemical methods for the presence of IgG. In 13 of 15 spinal
cords, a population of motoneurons stained positively for IgG in a granular pattern,
characteristic of binding to the rough endoplasmic reticulum. In 6 of 11 motor cortices, a
proportion of pyramidal cells also stained positively for IgG. No such reactivity was noted in
motoneurons of control human tissues, although positive IgG staining was present in …