Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation
Acute T-cell lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive hematopoietic
malignancy affecting both children and adults. Previous studies of T-ALL mouse models
induced by different genetic mutations have provided highly diverse results on the issues of
T-cell leukemia/lymphoma-initiating cells (T-LICs) and potential mechanisms contributing to
T-LIC transformation. Here, we show that oncogenic Kras (Kras G12D) expressed from its
endogenous locus is a potent inducer of T-ALL even in a less sensitized BALB/c …
malignancy affecting both children and adults. Previous studies of T-ALL mouse models
induced by different genetic mutations have provided highly diverse results on the issues of
T-cell leukemia/lymphoma-initiating cells (T-LICs) and potential mechanisms contributing to
T-LIC transformation. Here, we show that oncogenic Kras (Kras G12D) expressed from its
endogenous locus is a potent inducer of T-ALL even in a less sensitized BALB/c …
