[HTML][HTML] Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function
JS Palumbo, KA Barney, EA Blevins, MA Shaw… - Journal of Thrombosis …, 2008 - Elsevier
Background: Multiple studies suggest that the hemostatic and innate immune systems
functionally cooperate in establishing the fraction of tumor cells that successfully form
metastases. In particular, platelets and fibrinogen have been shown to support metastatic
potential through a mechanism coupled to natural killer (NK) cell function. As the
transglutaminase that ultimately stabilizes platelet/fibrin thrombi through the covalent
crosslinking of fibrin, factor (F) XIII is another thrombin substrate that is likely to support …
functionally cooperate in establishing the fraction of tumor cells that successfully form
metastases. In particular, platelets and fibrinogen have been shown to support metastatic
potential through a mechanism coupled to natural killer (NK) cell function. As the
transglutaminase that ultimately stabilizes platelet/fibrin thrombi through the covalent
crosslinking of fibrin, factor (F) XIII is another thrombin substrate that is likely to support …