[HTML][HTML] Influenza A virus-induced release of interleukin-10 inhibits the anti-microbial activities of invariant natural killer T cells during invasive pneumococcal …
A Barthelemy, S Ivanov, J Fontaine, D Soulard… - Mucosal …, 2017 - Elsevier
During influenza A virus (IAV) infection, changes in the lung's physical and immunological
defenses predispose the host to bacterial superinfections. Invariant natural killer T (iNKT)
cells are innate-like T lymphocytes that have beneficial or harmful functions during infection.
We investigated the iNKT cells' role in a model of invasive pneumococcal superinfection.
The use of Jα18−/− mice indicated that iNKT cells limited susceptibility to influenza-
pneumococcal infection and reduced the lethal synergism. This role did not depend on …
defenses predispose the host to bacterial superinfections. Invariant natural killer T (iNKT)
cells are innate-like T lymphocytes that have beneficial or harmful functions during infection.
We investigated the iNKT cells' role in a model of invasive pneumococcal superinfection.
The use of Jα18−/− mice indicated that iNKT cells limited susceptibility to influenza-
pneumococcal infection and reduced the lethal synergism. This role did not depend on …
