[HTML][HTML] Hemolytic uremic syndrome: a fatal outcome after kidney and liver transplantation performed to correct factor h gene mutation
G Remuzzi, P Ruggenenti, M Colledan… - American Journal of …, 2005 - Elsevier
Factor H-associated hemolytic uremic syndrome (HUS) is a genetic form of thrombotic
microangiopathy characterized by deficient factor H (HF-1) levels/activity and uncontrolled
complement activation. The disorder mostly leads to end-stage renal disease and often
recurs after kidney transplantation. We previously demonstrated that in a child with HF-1-
associated HUS a simultaneous kidney and liver transplantation restored the defective HF-1
with no recurrence of the disease in the transplanted kidney. Here we describe a second …
microangiopathy characterized by deficient factor H (HF-1) levels/activity and uncontrolled
complement activation. The disorder mostly leads to end-stage renal disease and often
recurs after kidney transplantation. We previously demonstrated that in a child with HF-1-
associated HUS a simultaneous kidney and liver transplantation restored the defective HF-1
with no recurrence of the disease in the transplanted kidney. Here we describe a second …
