Long-term studies of the natural history of asthma in childhood
H Bisgaard, K Bønnelykke - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
Segmentation of children with asthma and other wheezy disorders remains the main
research challenge today, as it was when described 2 centuries ago. Early childhood
wheezy disorders follow different temporal trajectories, probably representing different
underlying mechanisms (endophenotypes). Prospective identification of endophenotypes
allowing accurate prediction of the clinical course is currently not possible. The variability of
the clinical course remains an enigma and difficult to predict. Three of 4 school-aged …
research challenge today, as it was when described 2 centuries ago. Early childhood
wheezy disorders follow different temporal trajectories, probably representing different
underlying mechanisms (endophenotypes). Prospective identification of endophenotypes
allowing accurate prediction of the clinical course is currently not possible. The variability of
the clinical course remains an enigma and difficult to predict. Three of 4 school-aged …
