Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma
Background Childhood asthma in inner-city populations is a major public health burden, and
understanding early-life immune mechanisms that promote asthma onset is key to disease
prevention. Children with asthma demonstrate a high prevalence of aeroallergen
sensitization and TH 2-type inflammation; however, the early-life immune events that lead to
TH 2 skewing and disease development are unknown. Objective We sought to use RNA
sequencing of PBMCs collected at age 2 years to determine networks of immune responses …
understanding early-life immune mechanisms that promote asthma onset is key to disease
prevention. Children with asthma demonstrate a high prevalence of aeroallergen
sensitization and TH 2-type inflammation; however, the early-life immune events that lead to
TH 2 skewing and disease development are unknown. Objective We sought to use RNA
sequencing of PBMCs collected at age 2 years to determine networks of immune responses …