The environmental pollutant pyrene induces the production of IL-4
H Bömmel, M Li-Weber, E Serfling, A Duschl - Journal of allergy and clinical …, 2000 - Elsevier
Background: Epidemiologic studies and experiments with mouse models suggest that
polyaromatic hydrocarbons contained in, among others, diesel exhaust particles can
promote the development of allergy. Objective: Because IL-4 organizes allergic responses in
vivo, we have investigated whether pyrene, a major compound of diesel exhaust particles,
can affect the production of IL-4. Methods: IL-4 production by primary human T cells was
assessed by ELISA and messenger RNA transcription was detected by Northern blotting …
polyaromatic hydrocarbons contained in, among others, diesel exhaust particles can
promote the development of allergy. Objective: Because IL-4 organizes allergic responses in
vivo, we have investigated whether pyrene, a major compound of diesel exhaust particles,
can affect the production of IL-4. Methods: IL-4 production by primary human T cells was
assessed by ELISA and messenger RNA transcription was detected by Northern blotting …