Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules
EI Deryugina, JP Quigley - Methods in enzymology, 2008 - Elsevier
Angiogenesis plays a critical role in many normal physiological processes as well as in
tumor neovascularization associated with cancer progression. Among various animal model
systems designed to study the mechanisms underlying angiogenesis, chick embryo models
have been useful tools in analyzing the angiogenic potential of purified factors and intact
cells. The chorioallantoic membrane (CAM), a specialized, highly vascularized tissue of the
avian embryo, serves as an ideal indicator of the anti‐or pro‐angiogenic properties of test …
tumor neovascularization associated with cancer progression. Among various animal model
systems designed to study the mechanisms underlying angiogenesis, chick embryo models
have been useful tools in analyzing the angiogenic potential of purified factors and intact
cells. The chorioallantoic membrane (CAM), a specialized, highly vascularized tissue of the
avian embryo, serves as an ideal indicator of the anti‐or pro‐angiogenic properties of test …
