[HTML][HTML] CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
K Ganesh, S Adam, B Taylor, P Simpson… - Journal of Biological …, 2011 - ASBMB
Nuclear proteins typically contain short stretches of basic amino acids (nuclear localization
sequences; NLSs) that bind karyopherin α family members, directing nuclear import. Here,
we identify CTNNBL1 (catenin-β-like 1), an armadillo motif-containing nuclear protein that
exhibits no detectable primary sequence homology to karyopherin α, as a novel, selective
NLS-binding protein. CTNNBL1 (a single-copy gene conserved from fission yeast to man)
was previously found associated with Prp19-containing RNA-splicing complexes as well as …
sequences; NLSs) that bind karyopherin α family members, directing nuclear import. Here,
we identify CTNNBL1 (catenin-β-like 1), an armadillo motif-containing nuclear protein that
exhibits no detectable primary sequence homology to karyopherin α, as a novel, selective
NLS-binding protein. CTNNBL1 (a single-copy gene conserved from fission yeast to man)
was previously found associated with Prp19-containing RNA-splicing complexes as well as …
