TGFβ ligands, receptors and Smads.............................................................................................. 253 Defects in epiblast organization, gastrulation and mesoderm formation........................................ 254 Defects secondary to loss of signals from extraembryonic tissues................................................ 255 Defects due to a loss of BMP signals............................................................................................. 259 Defects in anterior development..................................................................................................... 259 Defects in progression of gastrulation............................................................................................ 259 Defects in cardiovascular system: vasculogenesis, angiogenesis and hematopoiesis.................. 260 Defects in establishment of left-right asymmetry............................................................................ 262 Gene dosage effect........................................................................................................................ 262 Postnatal phenotypes..................................................................................................................... 262 Summary........................................................................................................................................ 262 Acknowledgements........................................................................................................................ 263 References..................................................................................................................................... 263