Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies

A Fischer, J Provot, JP Jais, A Alcais… - Journal of Allergy and …, 2017 - Elsevier
Background Primary immunodeficiencies (PIDs) are inherited diseases associated with a
considerable increase in susceptibility to infections. It is known that PIDs can also
predispose to cancer and immune diseases, including allergy, autoimmunity, and
inflammation. Objective We aimed at determining the incidence of autoimmunity and
inflammation in patients with PIDs. Methods We have retrospectively screened 2183
consecutive cases of PID in the Centre de Référence Déficits Immunitaires Héréditaires …