[HTML][HTML] The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bβ2 antagonizes neuronal survival by promoting mitochondrial …
RK Dagda, RA Merrill, JT Cribbs, Y Chen… - Journal of Biological …, 2008 - ASBMB
The neurodegenerative disorder spinocerebellar ataxia 12 (SCA12) is caused by CAG
repeat expansion in the non-coding region of the PPP2R2B gene. PPP2R2B encodes Bβ1
and Bβ2, alternatively spliced and neuron-specific regulatory subunits of the protein
phosphatase 2A (PP2A) holoenzyme. We show here that in PC12 cells and hippocampal
neurons, cell stressors induced a rapid translocation of PP2A/Bβ2 to mitochondria to
promote apoptosis. Conversely, silencing of PP2A/Bβ2 protected hippocampal neurons …
repeat expansion in the non-coding region of the PPP2R2B gene. PPP2R2B encodes Bβ1
and Bβ2, alternatively spliced and neuron-specific regulatory subunits of the protein
phosphatase 2A (PP2A) holoenzyme. We show here that in PC12 cells and hippocampal
neurons, cell stressors induced a rapid translocation of PP2A/Bβ2 to mitochondria to
promote apoptosis. Conversely, silencing of PP2A/Bβ2 protected hippocampal neurons …