Akt/PKB is a key master regulator of a wide range of physiological functions including
metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The
Akt protein kinase family comprises three highly related isoforms encoded by different
genes. The initial observation that the Akt isoforms share upstream activators as well as
several downstream effectors, together with the high sequence homology suggested that
their functions were mostly redundant. By contrast, an increasing body of evidence has …