[PDF][PDF] Stem cells cycle toward immune surveillance
AS Boyd, NP Rodrigues - Immunity, 2018 - cell.com
AS Boyd, NP Rodrigues
Immunity, 2018•cell.comStem Cells Cycle toward Immune Surveillance Page 1 fates? Or does it represent fine tuning of
small regions of a genome that is already preconfigured? Do these principals of locking in fate
determination via modulation of higher-order chromatin structures apply to other immune cell
lineages? Given the interest in ‘‘reprogramming’’ immune cells for immunotherapies, providing
answers to these fundamental questions will be critical for ensuring success. REFERENCES
Dekker, J., and Heard, E. (2015). Structural and functional diversity of topologically associating …
small regions of a genome that is already preconfigured? Do these principals of locking in fate
determination via modulation of higher-order chromatin structures apply to other immune cell
lineages? Given the interest in ‘‘reprogramming’’ immune cells for immunotherapies, providing
answers to these fundamental questions will be critical for ensuring success. REFERENCES
Dekker, J., and Heard, E. (2015). Structural and functional diversity of topologically associating …
Immune surveillance is an established regulatory mechanism that spares tissues from malignant transformation. Agudo et al. (2018) find that the chief cell type to generate tissues in the body—somatic stem cells—is subject to immune surveillance only during proliferation.
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