Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus
Q Cheng, X Wang, Y Shen, Y Shen, B Zu, J Xu… - The American journal of …, 2014 - Elsevier
Systemic lupus erythematosus (SLE) is an autoimmune disease with uncertain
pathogenesis. Endoplasmic reticulum (ER) stress has close correlations with inflammation
and/or immune diseases. However, it is unknown whether aberrant ER stress is involved in
SLE pathogenesis. We aimed to characterize the ER stress-related genes in patients with
SLE and analyzed their correlations with the disease. Peripheral blood leucocytes were
isolated from 76 well-characterized patients with SLE and 69 healthy controls. ER stress …
pathogenesis. Endoplasmic reticulum (ER) stress has close correlations with inflammation
and/or immune diseases. However, it is unknown whether aberrant ER stress is involved in
SLE pathogenesis. We aimed to characterize the ER stress-related genes in patients with
SLE and analyzed their correlations with the disease. Peripheral blood leucocytes were
isolated from 76 well-characterized patients with SLE and 69 healthy controls. ER stress …
