Much modern research is quite focused, attempting to understand aspects of systems that
are already revealed in broad outline. Researching a problem at its birth is an opportunity
that many will never experience, a lonely exercise that many may avoid. In these situations,
pre-existing findings from other scientists offer only limited help. Years or even decades may
be necessary to make real progress, and most discouragingly, the initial surprising findings
may be of limited interest to scientists focused on more established systems or problems …

DH Raulet, Bone marrow cell rejection, MHC, NK cells, and missing self recognition: Ain't
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