[HTML][HTML] Tolerance induction by third-party “off-the-shelf” CD4+ CD25+ Treg cells
D Steiner, N Brunicki, BR Blazar, E Bachar-Lustig… - Experimental …, 2006 - Elsevier
OBJECTIVE: Recent reports have shown that donor or host CD4+ CD25+ Treg cells can be
used to control GVHD or graft rejection following allogeneic BMT in mice. In the present
study we investigated the potential of third-party Treg cells compared to donor-type cells to
facilitate BM allografting. METHODS: Graft rejection is assessed in a mouse model of T cell–
mediated BM allograft rejection. Lethally irradiated C3H mice are transplanted at day 2 after
irradiation with T cell–depleted Balb/Nude BM. Graft rejection is induced by purified host …
used to control GVHD or graft rejection following allogeneic BMT in mice. In the present
study we investigated the potential of third-party Treg cells compared to donor-type cells to
facilitate BM allografting. METHODS: Graft rejection is assessed in a mouse model of T cell–
mediated BM allograft rejection. Lethally irradiated C3H mice are transplanted at day 2 after
irradiation with T cell–depleted Balb/Nude BM. Graft rejection is induced by purified host …
