Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients
NHR Litjens, M Huisman… - Journal of the …, 2008 - journals.lww.com
Serologic responses to T cell–dependent vaccinations are severely attenuated in patients
with ESRD, but the reasons for this is unknown. In this study, a detailed analysis of antigen-
specific T cell responses was performed. Patients on hemodialysis and age-and gender-
matched healthy control subjects were vaccinated with hepatitis B surface antigen (HBsAg),
antigen-specific CD4+ T cells were monitored at regular intervals with intracellular cytokine
staining and proliferation assays. IL-2–and IFN-γ–producing CD4+ T cells were identified as …
with ESRD, but the reasons for this is unknown. In this study, a detailed analysis of antigen-
specific T cell responses was performed. Patients on hemodialysis and age-and gender-
matched healthy control subjects were vaccinated with hepatitis B surface antigen (HBsAg),
antigen-specific CD4+ T cells were monitored at regular intervals with intracellular cytokine
staining and proliferation assays. IL-2–and IFN-γ–producing CD4+ T cells were identified as …