Whole-Genome Sequences of Thirteen Isolates of Borrelia burgdorferi
SE Schutzer, CM Fraser-Liggett, SR Casjens… - Journal of …, 2011 - Am Soc Microbiol
Journal of bacteriology, 2011•Am Soc Microbiol
Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The
first complete genome sequence of B. burgdorferi strain 31, available for more than a
decade, has assisted research on the pathogenesis of Lyme disease. Because a single
genome sequence is not sufficient to understand the relationship between genotypic and
geographic variation and disease phenotype, we determined the whole-genome sequences
of 13 additional B. burgdorferi isolates that span the range of natural variation. These …
first complete genome sequence of B. burgdorferi strain 31, available for more than a
decade, has assisted research on the pathogenesis of Lyme disease. Because a single
genome sequence is not sufficient to understand the relationship between genotypic and
geographic variation and disease phenotype, we determined the whole-genome sequences
of 13 additional B. burgdorferi isolates that span the range of natural variation. These …
Abstract
Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.
American Society for Microbiology