Role of Nef in HIV‐1 replication and pathogenesis
JL Foster, JV Garcia - Advances in pharmacology, 2007 - Elsevier
Publisher Summary This chapter describes the role of Nef in human immunodeficiency virus
type 1 (HIV‐1) replication and pathogenesis. Nef is a pathogenic factor of HIV. The
assessment of the role of Nef in the development of AIDS require model systems that reflect
to a significant degree the anatomical, developmental, and regulatory features of the human
immune system under assault by HIV‐1. Relatively simple in vitro HIV‐1 infection models
include peripheral blood mononuclear cells (PBMCs), T cells, dendritic cell–T cell …
type 1 (HIV‐1) replication and pathogenesis. Nef is a pathogenic factor of HIV. The
assessment of the role of Nef in the development of AIDS require model systems that reflect
to a significant degree the anatomical, developmental, and regulatory features of the human
immune system under assault by HIV‐1. Relatively simple in vitro HIV‐1 infection models
include peripheral blood mononuclear cells (PBMCs), T cells, dendritic cell–T cell …