[HTML][HTML] Bacterial immunogenic α-galactosylceramide identified in the murine large intestine: dependency on diet and inflammation
J von Gerichten, D Lamprecht, L Opálka… - Journal of lipid …, 2019 - ASBMB
The glycosphingolipid, α-galactosylceramide (αGalCer), when presented by CD1d on
antigen-presenting cells, efficiently activates invariant natural killer T (iNKT) cells. Thereby, it
modulates immune responses against tumors, microbial and viral infections, and
autoimmune diseases. Recently, the production of αGalCer by Bacteroidetes from the
human gut microbiome was elucidated. Using hydrophilic interaction chromatography
coupled to MS 2, we screened murine intestinal tracts to identify and quantify αGalCers, and …
antigen-presenting cells, efficiently activates invariant natural killer T (iNKT) cells. Thereby, it
modulates immune responses against tumors, microbial and viral infections, and
autoimmune diseases. Recently, the production of αGalCer by Bacteroidetes from the
human gut microbiome was elucidated. Using hydrophilic interaction chromatography
coupled to MS 2, we screened murine intestinal tracts to identify and quantify αGalCers, and …