Comparative hepatotoxicity of cholic acid, deoxycholic acid and lithocholic acid in the rat: in vivo and in vitro studies
NM Delzenne, PB Calderon, HS Taper, MB Roberfroid - Toxicology letters, 1992 - Elsevier
Until now, the cytotoxicity of the bile acids was mostly seen as being inversely associated
with their degree of lipophilicity. The present study aimed at comparing the hepatotoxicity of
cholic acid (CA), deoxycholic acid (DCA) and lithocholic acid (LCA), which are respectively,
tri-, di-and monohydroxylated bile acids. For in vivo studies, the bile acids have been given
at the dose of 0.5% or 1% in the diet of male Wistar rats for 2 weeks. The histological
analysis of the liver, and the measurement of serum parameters of cytotoxicity and …
with their degree of lipophilicity. The present study aimed at comparing the hepatotoxicity of
cholic acid (CA), deoxycholic acid (DCA) and lithocholic acid (LCA), which are respectively,
tri-, di-and monohydroxylated bile acids. For in vivo studies, the bile acids have been given
at the dose of 0.5% or 1% in the diet of male Wistar rats for 2 weeks. The histological
analysis of the liver, and the measurement of serum parameters of cytotoxicity and …