Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice
S Gong, T Lan, L Zeng, H Luo, X Yang, NA Li… - Journal of …, 2018 - Elsevier
Background & Aims Acetaminophen (APAP) induced hepatotoxicity is a leading cause of
acute liver failure worldwide. It is well established that the liver damage induced by
acetaminophen exhibits diurnal variation. However, the detailed mechanism for the
hepatotoxic variation is not clear. Herein, we aimed to determine the relative contributions of
gut microbiota in modulating the diurnal variation of hepatotoxicity induced by APAP.
Methods Male Balb/C mice were treated with or without antibiotics and a single dose of …
acute liver failure worldwide. It is well established that the liver damage induced by
acetaminophen exhibits diurnal variation. However, the detailed mechanism for the
hepatotoxic variation is not clear. Herein, we aimed to determine the relative contributions of
gut microbiota in modulating the diurnal variation of hepatotoxicity induced by APAP.
Methods Male Balb/C mice were treated with or without antibiotics and a single dose of …