Bile acids as carcinogens in human gastrointestinal cancers
H Bernstein, C Bernstein, CM Payne… - … Research/Reviews in …, 2005 - Elsevier
Bile acids were first proposed to be carcinogens in 1939 and 1940. On the basis of later
work with rodent models, bile acids came to be regarded as cancer promoters rather than
carcinogens. However, considerable indirect evidence, obtained more recently, supports the
view that bile acids are carcinogens in humans. At least 15 reports, from 1980 through 2003,
indicate that bile acids cause DNA damage. The mechanism is probably indirect, involving
induction of oxidative stress and production of reactive oxygen species that then damage …
work with rodent models, bile acids came to be regarded as cancer promoters rather than
carcinogens. However, considerable indirect evidence, obtained more recently, supports the
view that bile acids are carcinogens in humans. At least 15 reports, from 1980 through 2003,
indicate that bile acids cause DNA damage. The mechanism is probably indirect, involving
induction of oxidative stress and production of reactive oxygen species that then damage …
