[HTML][HTML] Secondary bile acids: an underrecognized cause of colon cancer
World journal of surgical oncology, 2014•Springer
Bile acids were first proposed as carcinogens in 1939. Since then, accumulated evidence
has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels
of bile acids as an important risk factor for gastrointestinal cancers. High exposure to bile
acids may occur in a number of settings, but most importantly, is prevalent among
individuals who have a high dietary fat intake. A rapid effect on cells of high bile acid
exposure is the generation of reactive oxygen species and reactive nitrogen species …
has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels
of bile acids as an important risk factor for gastrointestinal cancers. High exposure to bile
acids may occur in a number of settings, but most importantly, is prevalent among
individuals who have a high dietary fat intake. A rapid effect on cells of high bile acid
exposure is the generation of reactive oxygen species and reactive nitrogen species …
Abstract
Bile acids were first proposed as carcinogens in 1939. Since then, accumulated evidence has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels of bile acids as an important risk factor for gastrointestinal cancers. High exposure to bile acids may occur in a number of settings, but most importantly, is prevalent among individuals who have a high dietary fat intake.
A rapid effect on cells of high bile acid exposure is the generation of reactive oxygen species and reactive nitrogen species, disruption of the cell membrane and mitochondria, induction of DNA damage, mutation and apoptosis, and development of reduced apoptosis capability upon chronic exposure. Here, we review the substantial evidence of the mechanism of secondary bile acids and their role in colon cancer.
Springer
