Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with
important roles in the suppression of tumor metastasis and in the reproduction. The aim of
the present study is to clarify changes of the expression of kisspeptins and kisspeptin
receptor in the kidney with and without chronic renal impairment. 5/6 nephrectomized rats
were used as the rat model of chronic renal failure. Competitive quantitative RT-PCR
showed that kisspeptin mRNA levels were decreased in the kidney of 5/6 nephrectomized …