Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice
Y Kamari, A Shaish, E Vax, S Shemesh… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: The identification of the cellular and molecular pathways that
mediate the development of non-alcoholic steatohepatitis is of crucial importance. Cytokines
produced by liver-resident and infiltrating inflammatory cells, play a pivotal role in liver
inflammation. The role of the proinflammatory cytokines IL-1α and IL-1β in steatohepatitis
remains elusive. METHODS: We employed IL-1α and IL-1β-deficient mice and transplanted
marrow cells to study the role of liver-resident and bone marrow-derived IL-1 in steatosis …
mediate the development of non-alcoholic steatohepatitis is of crucial importance. Cytokines
produced by liver-resident and infiltrating inflammatory cells, play a pivotal role in liver
inflammation. The role of the proinflammatory cytokines IL-1α and IL-1β in steatohepatitis
remains elusive. METHODS: We employed IL-1α and IL-1β-deficient mice and transplanted
marrow cells to study the role of liver-resident and bone marrow-derived IL-1 in steatosis …