[HTML][HTML] A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
A Asgharpour, SC Cazanave, T Pacana… - Journal of …, 2016 - Elsevier
Background & Aims The lack of a preclinical model of progressive non-alcoholic
steatohepatitis (NASH) that recapitulates human disease is a barrier to therapeutic
development. Methods A stable isogenic cross between C57BL/6J (B6) and 129S1/SvImJ
(S129) mice were fed a high fat diet with ad libitum consumption of glucose and fructose in
physiologically relevant concentrations and compared to mice fed a chow diet and also to
both parent strains. Results Following initiation of the obesogenic diet, B6/129 mice …
steatohepatitis (NASH) that recapitulates human disease is a barrier to therapeutic
development. Methods A stable isogenic cross between C57BL/6J (B6) and 129S1/SvImJ
(S129) mice were fed a high fat diet with ad libitum consumption of glucose and fructose in
physiologically relevant concentrations and compared to mice fed a chow diet and also to
both parent strains. Results Following initiation of the obesogenic diet, B6/129 mice …