Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-
related death globally. Hepatocellular carcinoma represents about 90% of primary liver
cancers and constitutes a major global health problem. The following Clinical Practice
Guidelines will give up-to-date advice for the clinical management of patients with
hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data
leading to the conclusions herein.