Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
RK Sterling, E Lissen, N Clumeck, R Sola… - Hepatology, 2006 - journals.lww.com
Methods. Of the 868 patients enrolled in APRICOT, 832 were included in the analysis. Thirty‐
six patients were excluded because of lack of interpretable histology. Liver histology was
determined via Ishak score 40 as assessed by local pathologists (from 95 centers in 19
countries). Total histological activity index and fibrosis scores (0–6) were recorded. For
analysis, patients were categorized into 3 fibrosis strata: mild (Ishak fibrosis score 0–1),
moderate (Ishak fibrosis score 2–3), and advanced (Ishak fibrosis score 4–6). Significant …
six patients were excluded because of lack of interpretable histology. Liver histology was
determined via Ishak score 40 as assessed by local pathologists (from 95 centers in 19
countries). Total histological activity index and fibrosis scores (0–6) were recorded. For
analysis, patients were categorized into 3 fibrosis strata: mild (Ishak fibrosis score 0–1),
moderate (Ishak fibrosis score 2–3), and advanced (Ishak fibrosis score 4–6). Significant …