[HTML][HTML] Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4α (HNF4α): HNF4α regulates ornithine transcarbamylase in …
Y Inoue, GP Hayhurst, J Inoue, M Mori… - Journal of Biological …, 2002 - ASBMB
Hepatocyte nuclear factor 4α (HNF4α) regulates the expression of many genes preferentially
expressed in liver. HNF4α-null mice die during embryogenesis precluding the analysis of its
function in the adult. To circumvent this problem, liver-specific HNF4α-null mice were
produced. Mice lacking hepatic HNF4α expression exhibited increased serum ammonia and
reduced serum urea. This disruption in ureagenesis may be explained by a marked
decrease in expression and activity of hepatic ornithine transcarbamylase (OTC). To …
expressed in liver. HNF4α-null mice die during embryogenesis precluding the analysis of its
function in the adult. To circumvent this problem, liver-specific HNF4α-null mice were
produced. Mice lacking hepatic HNF4α expression exhibited increased serum ammonia and
reduced serum urea. This disruption in ureagenesis may be explained by a marked
decrease in expression and activity of hepatic ornithine transcarbamylase (OTC). To …