[HTML][HTML] The retina and retinal pigment epithelium differ in nitrogen metabolism and are metabolically connected
R Xu, BK Ritz, Y Wang, J Huang, C Zhao… - Journal of Biological …, 2020 - ASBMB
Defects in energy metabolism in either the retina or the immediately adjacent retinal pigment
epithelium (RPE) underlie retinal degeneration, but the metabolic dependence between
retina and RPE remains unclear. Nitrogen-containing metabolites such as amino acids are
essential for energy metabolism. Here, we found that 15 N-labeled ammonium is
predominantly assimilated into glutamine in both the retina and RPE/choroid ex vivo.[15 N]
Ammonium tracing in vivo show that, like the brain, the retina can synthesize asparagine …
epithelium (RPE) underlie retinal degeneration, but the metabolic dependence between
retina and RPE remains unclear. Nitrogen-containing metabolites such as amino acids are
essential for energy metabolism. Here, we found that 15 N-labeled ammonium is
predominantly assimilated into glutamine in both the retina and RPE/choroid ex vivo.[15 N]
Ammonium tracing in vivo show that, like the brain, the retina can synthesize asparagine …