[PDF][PDF] The dawn of the age of amino acid sensors for the mTORC1 pathway
RL Wolfson, DM Sabatini - Cell metabolism, 2017 - cell.com
RL Wolfson, DM Sabatini
Cell metabolism, 2017•cell.comThe mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell
growth that responds to a diverse set of environmental inputs, including amino acids. Over
the past 10 years, a number of proteins have been identified that help transmit amino acid
availability to mTORC1. However, amino acid sensors for this pathway have only recently
been discovered. Here, we review these recent advances and highlight the variety of
unexplored questions that emerge from the identification of these sensors.
growth that responds to a diverse set of environmental inputs, including amino acids. Over
the past 10 years, a number of proteins have been identified that help transmit amino acid
availability to mTORC1. However, amino acid sensors for this pathway have only recently
been discovered. Here, we review these recent advances and highlight the variety of
unexplored questions that emerge from the identification of these sensors.
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.
cell.com