[HTML][HTML] Novel aspects of glutamine synthetase in ammonia homeostasis
Y Zhou, T Eid, B Hassel, NC Danbolt - Neurochemistry international, 2020 - Elsevier
Elevated blood ammonia (hyperammonemia) is believed to be a major contributor to the
neurological sequelae following severe liver disease. Ammonia is cleared via two main
mechanisms, the urea cycle pathway and the glutamine synthetase reaction. Recent studies
of genetically modified animals confirm the importance of the urea cycle, but also suggest
that the glutamine synthetase reaction is more important than previously recognized. While
the liver clears about two-thirds of the body's ammonia via the combined action of the urea …
neurological sequelae following severe liver disease. Ammonia is cleared via two main
mechanisms, the urea cycle pathway and the glutamine synthetase reaction. Recent studies
of genetically modified animals confirm the importance of the urea cycle, but also suggest
that the glutamine synthetase reaction is more important than previously recognized. While
the liver clears about two-thirds of the body's ammonia via the combined action of the urea …