[HTML][HTML] Sec24 proteins and sorting at the endoplasmic reticulum
A Pagano, F Letourneur, D Garcia-Estefania… - Journal of Biological …, 1999 - ASBMB
COPII proteins are necessary to generate secretory vesicles at the endoplasmic reticulum. In
yeast, the Sec24p protein is the only COPII component in which two close orthologues have
been identified. By using gene knock-out in yeast, we found that the absence of one of these
Sec24 orthologues resulted in a selective secretion defect for a subset of proteins released
into the medium. Data base searches revealed the existence of an entire family of Sec24-
related proteins in humans, worms, flies, and plants. We identified and cloned two new …
yeast, the Sec24p protein is the only COPII component in which two close orthologues have
been identified. By using gene knock-out in yeast, we found that the absence of one of these
Sec24 orthologues resulted in a selective secretion defect for a subset of proteins released
into the medium. Data base searches revealed the existence of an entire family of Sec24-
related proteins in humans, worms, flies, and plants. We identified and cloned two new …
