[HTML][HTML] Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers
YK Lee, KL Parker, HS Choi, DD Moore - Journal of Biological Chemistry, 1999 - ASBMB
Small heterodimer partner (SHP) is an orphan nuclear receptor that lacks a conventional
DNA binding domain. It interacts with several other members of the nuclear receptor
superfamily and inhibits receptor transactivation. In order to characterize the regulation of
SHP expression, a number of receptors and other transcription factors were tested for effects
on the SHP promoter. Among these, the orphan receptor steroidogenic factor-1 (SF-1) was
found to potently transactivate the SHP promoter. Detailed footprinting studies show that the …
DNA binding domain. It interacts with several other members of the nuclear receptor
superfamily and inhibits receptor transactivation. In order to characterize the regulation of
SHP expression, a number of receptors and other transcription factors were tested for effects
on the SHP promoter. Among these, the orphan receptor steroidogenic factor-1 (SF-1) was
found to potently transactivate the SHP promoter. Detailed footprinting studies show that the …