High-mobility group box 1 exacerbates CCl4-induced acute liver injury in mice
M Chen, W Huang, C Wang, H Nie, G Li, T Sun… - Clinical …, 2014 - Elsevier
High-mobility group box 1 (HMGB1) is a nuclear factor that can also serve as an
imflammatory mediator once released into extracellular milieu. Therefore, HMGB1 has been
recognized to play a pivotal role in inflammatory diseases such as sepsis, acute lung injury,
ischemia reperfusion injury and type 1 diabetes. Nevertheless, its impact on carbon
tetrachloride (CCl 4)-induced hepatic injury is yet to be elucidated. In the present report, we
demonstrated evidence indicating that high levels of HMGB1 were not only present in the …
imflammatory mediator once released into extracellular milieu. Therefore, HMGB1 has been
recognized to play a pivotal role in inflammatory diseases such as sepsis, acute lung injury,
ischemia reperfusion injury and type 1 diabetes. Nevertheless, its impact on carbon
tetrachloride (CCl 4)-induced hepatic injury is yet to be elucidated. In the present report, we
demonstrated evidence indicating that high levels of HMGB1 were not only present in the …