[HTML][HTML] Two distinct Raf domains mediate interaction with Ras (∗)
TR Brtva, JK Drugan, S Ghosh, RS Terrell… - Journal of Biological …, 1995 - ASBMB
A key event for Ras transformation involves the direct physical association between Ras and
the Raf-1 kinase. This interaction promotes both Raf translocation to the plasma membrane
and activation of Raf kinase activity. Although substantial experimental evidence has
demonstrated that Raf residues 51-131 alone are sufficient for Ras binding, conflicting
observations have suggested that the Raf cysteine-rich domain (residues 139-184) may also
be important for interaction with Ras. To clarify the role of the Raf cysteine-rich domain in …
the Raf-1 kinase. This interaction promotes both Raf translocation to the plasma membrane
and activation of Raf kinase activity. Although substantial experimental evidence has
demonstrated that Raf residues 51-131 alone are sufficient for Ras binding, conflicting
observations have suggested that the Raf cysteine-rich domain (residues 139-184) may also
be important for interaction with Ras. To clarify the role of the Raf cysteine-rich domain in …
